D-Biotin

Also known as : Biotin, D-(+)-biotin, Vitamin B7, Vitamin H, Coenzyme R, Biotina

Biotin is a water-soluble B-vitamin, a natural product found largely in the kidney, liver, egg yolk, milk and yeast. The compound is used to prevent symptoms of eggwhite injury in experimental animals. Its prime medical use is in various dermatitides. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis.
Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. Biotin assists in various metabolic reactions involving the transfer of carbon dioxide. It may also be helpful in maintaining a steady blood sugar level. Biotin is often recommended as a dietary supplement for strengthening hair and nails, though scientific data supporting this outcome are weak. Nevertheless, biotin is found in many cosmetics and health products for the hair and skin.
Biotin deficiency typically occurs from dietary absence of the vitamin. Consuming raw egg whites over months may result in biotin deficiency. Deficiency can be addressed with nutritional supplementation. Deficiency symptoms include:

Brittle and thin fingernails

Hair loss (alopecia)

Conjunctivitis

Dermatitis in the form of a scaly, red rash around the eyes, nose, mouth, and genital area.

Neurological symptoms in adults, such as depression, lethargy, hallucination, and numbness and tingling of the extremities

The neurological and psychological symptoms can occur with only mild deficiencies. Dermatitis, conjunctivitis, and hair loss will generally occur only when deficiency becomes more severe. Individuals with hereditary disorders of biotin deficiency have evidence of impaired immune system function, including increased susceptibility to bacterial and fungal infections.
Pregnant women tend to have a high risk of biotin deficiency. Nearly half of pregnant women have abnormal increases of 3-hydroxyisovaleric acid, which reflects reduced status of biotin. Several studies have reported this possible biotin deficiency during the pregnancy may cause infants' congenital malformations, such as cleft palate. Mice fed with dried raw egg to induce biotin deficiency during the gestation resulted in up to 100% incidence of the infants' malnourishment. Infants and embryos are more sensitive to the biotin deficiency. Therefore, even a mild level of the mother's biotin deficiency that does not reach the appearance of physiological deficiency signs may cause a serious consequence in the infants.

Hence, D-Biotin or its preparation / premixture is used widly as food, feed additive, it is an important vitamin supplements

Line Formula: C₁₀H₁₆N₂O₃S

CAS No: 58-85-5

Structure:

We mainly provide below items into markets

Category	Product Name	Chemical Entity
Active Pharmaecutical Ingredient (API)	D-Biotin (Pure)	USP/EP
Food Additive	1% D-Biotin on DCP	REGULATION (EU) No 609/2013 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 12 June 2013 on food intended for infants and young children, food for special medical purposes GB 1903.25-2016 食品安全国家标准 食品营养强化剂 D-生物素
Feed Additive	2% D-Biotin on Maltodextrin	COMMISSION IMPLEMENTING REGULATION (EU) 2015/723 of 5 May 2015 concerning the authorisation of biotin as a feed additive for all animal species GB 36898-2018 饲料添加剂 D-生物素 GB/T 23180-2008 饲料添加剂 2% D-生物素
Feed Additive	10% D-Biotin on Maltodextrin	REGULATION (EU) No 609/2013 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 12 June 2013 on food intended for infants and young children, food for special medical purposes GB 1903.25-2016 食品安全国家标准 食品营养强化剂 D-生物素