Also known as : S-benzoylthiamine O-monophosphate, S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate Benphothiamine; 苯磷硫胺[Chinese] �ベンフォチアミン [Japanese]
Benfotiamine (or S-benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It is known as vitamin B1 lipid-soluble derivatives, improved water-soluble vitamins B1 low bioavailability of disadvantages, it is prescribed for treating sciatica and other painful nerve conditions. It is marketed as a medicine and/or an antioxidant dietary supplement.
Benfotiamine may be useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy as it lowered AGE by 40%,
It is thought that treatment with benfotiamine leads to increased intracellular thiamine diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products substrates to the pentose phosphate pathway, thus reducing tissue AGEs
As Pharmacology, After intake and absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine. Benfotiamine should not be confused with allithiamine, a naturally occurring thiamine disulfide derivative with a distinct pharmacological profile.
Benphothiamine can increase blood and tissues, Thiamine concentration, thereby enhancing efficacy. The primary application to the following aspects
Benfotiamine is produced by our controlling subsidiary company name after Zhejiang Changming Pharmaecutical Co., Ltd.
Line Formula: C19H23N4O6PS
CAS No: 22457-89-2