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Also known as : S-benzoylthiamine O-monophosphate, S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate Benphothiamine; 苯磷硫胺[Chinese] �ベンフォチアミン [Japanese]

Benfotiamine (or S-benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It is known as vitamin B1 lipid-soluble derivatives, improved water-soluble vitamins B1 low bioavailability of disadvantages, it is prescribed for treating sciatica and other painful nerve conditions. It is marketed as a medicine and/or an antioxidant dietary supplement.
Benfotiamine may be useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy as it lowered AGE by 40%,
It is thought that treatment with benfotiamine leads to increased intracellular thiamine diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products substrates to the pentose phosphate pathway, thus reducing tissue AGEs
As Pharmacology, After intake and absorption, benfotiamine can be dephosphorylated by cells bearing an ecto-alkaline phosphatase to the lipid-soluble S-benzoylthiamine. Benfotiamine should not be confused with allithiamine, a naturally occurring thiamine disulfide derivative with a distinct pharmacological profile.

Benphothiamine can increase blood and tissues, Thiamine concentration, thereby enhancing efficacy. The primary application to the following aspects

  • for thiamine deficiency disease prevention and treatment;
  • vitamin B 1 demand increases, from the food uptake is not sufficient make-up, fatigue, hyperthyroidism, gestation, lactation, vigorous manual labor, etc. ;
  • for the treatment of non-l lopinavir, grams of brain disease;
  • for the treatment of foot disease;
  • for the disease, the speculative and thiamine deficiency and metabolic disorders associated with treatment, such as: neuropathic pain; muscle pain, joint pain ?;
  • Peripheral-inflammatory, peripheral nerveThe paralysis;
  • myocardial metabolism disorders, constipation, gastrointestinal motility dysfunction.
  • The benfotiamine as Vitamin B1 supplemental have been marketed in the United States, Japan, Europe, etc worldwide market. Recent studies have shown that, benfotiamine in diabetic peripheral neuropathy and retinopathy of significant therapeutic effect. In addition, benfotiamine may also be applied to the prevention and treatment of alzheimer��s disease, and aging.

    Benfotiamine is produced by our controlling subsidiary company name after Zhejiang Changming Pharmaecutical Co., Ltd.

    Line Formula: C19H23N4O6PS

    CAS No: 22457-89-2